proteína TDP-43 em ALS esporádica e herdada...

Gene Newly Linked To Inherited ALS May Also Play Role In Common Dementia
Article Date: 21 Feb 2008 - 0:00 PST

Scientists at Washington University School of Medicine in St. Louis have linked a mutation in a gene known as TDP-43 to an inherited form of amyotrophic lateral sclerosis (ALS), the neurodegenerative condition often called Lou Gehrig's disease.

Researchers found the connection intriguing because studies by other groups have revealed abnormalities in the TDP-43 protein in both sporadic and inherited ALS, as well as in several other neurodegenerative disorders.

"The potential link to sporadic ALS is particularly interesting. If we can confirm TDP-43's association with inherited ALS, mutating this gene may give us a way to model sporadic ALS in laboratory animals for the first time," says senior author Nigel Cairns, Ph.D., research associate professor of neurology and pathology and immunology. "That could give us a potent tool for better understanding ALS and developing new treatments."

The study appears February 20 in Annals of Neurology. It was conducted at the Hope Center for Neurological Disorders, a partnership between the University and Hope Happens, a St. Louis-based non-profit organization dedicated to raising funds for neurological research.

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O Gene Ligou Recentemente a ALS Herdado Pode Também Jogar O Papel Na Data Comum Do Artigo Do Dementia: 21 Fevereiro 2008 - 0:00 PST Os cientistas na escola da universidade de Washington da medicina em St. Louis ligaram um mutation em um gene sabido como TDP-43 a um formulário herdado do sclerosis de lateral amyotrophic (ALS), a doença de Lou Gehrig frequentemente chamado neurodegenerative da circunstância. Os investigadores encontraram a conexão intriguing porque os estudos por outros grupos revelaram abnormalities na proteína TDP-43 em ALS esporádico e herdado, as.well.as em diversos outros disorders neurodegenerative. "a ligação potencial a ALS esporádico é particularmente interessante. Se nós pudermos confirmar a associação de TDP-43's com ALS herdado, mutating este gene pode dar-nos uma maneira modelar a primeira vez ALS esporádico em animais de laboratório para, "diz os cairns sênior de Nigel do autor, Ph.D., professor de associado da pesquisa do neurology e o pathology e o immunology. "que poderia nos dar uma ferramenta potent para ALS compreensivo melhor e tratamentos novos se tornando." O estudo aparece fevereiro 20 nos annals do neurology. Foi conduzido no centro para disorders neurological, uma parceria da esperança entre a universidade e a esperança acontece, uma organização non-profit Louis-baseada St. dedicada a levantar fundos para a pesquisa neurological...